Low-frequency pulsed electromagnetic field inhibits RANKL-induced osteoclastic differentiation in RAW264.7 cells by scavenging reactive oxygen species

Disclaimer: this research study’s copyright belongs to the authors and PubMed and not HealthMatReview.com, further details below.

Our Summary

Low-frequency PEMF has shown to be effective in treating osteoporosis but the exact process has yet to be verified. With this, the project aims to test the effectivity of PEMF exerts on intracellular reactive oxygen species (ROS) production and receptor activator of nuclear factor-?B ligand (RANKL)-induced osteoclast genesis. Cells were exposed to PEMF with 75 Hz frequency and 1 mT intensity. Results showed the inhibitory effect of PEMF on RANKL-induced osteoclastic differentiation and decreased intracellular ROS generation during osteoclastic differentiation. This may serve as the groundwork for future osteoclast-associated bone disease treatment using PEMF.

Pubmed Study Link

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470919/

PDF Study Link

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470919/pdf/mmr-19-05-4129.pdf

Study Categories

back pain, bone healing, brittle bone, pain relief

Authors

[‘Ying Pi’, ‘Haifeng Liang’, ‘Qiang Yu’, ‘Yukun Yin’, ‘Haixia Xu’, ‘Yutian Lei’, ‘Zhongyu Han’, ‘Jing Tian’]

PMID

30942408

PMCID

PMC6470919

Published Date

more study details

Frequency (Hz)

75

Frequency Range

High

Intensity (G)

10

Intensity Range

Low

Waveform

sine

PEMF/EMF/RF/LT

PEMF

Study Subject Types

human

Keywords Listed

pulsed electromagnetic field, osteoclast, differentiation, reactive oxygen species, receptor activator of nuclear factor-?B signaling

Added Descriptive Keywords

brittle bone, spine, broken bone, back pain, osteoporosis, human

Disclaimer

All intellectual property and copyright of this research study sourced from PubMed, is the property of the authors and associates and is not the property of HealthMatReview.com. This research study has been included in our custom PEMF research database for the educational purposes of our readers. The on page summary, added descriptive keywords and other study details are copyright of HealthMatReview.com and were added to improve the search function of this custom research database.

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