Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3?/?-catenin axis in mesenchymal stem cells under osteogenic induction

Disclaimer: this research study’s copyright belongs to the authors and PubMed and not HealthMatReview.com, further details below.

Our Summary

The objective of this study is to investigate the effects of EMF on purinergic receptor P2X7 and its potential in osteoporosis therapy. Human bone marrow mesenchymal stem cells (h-MSC) were exposed to EMF and P2X7 expression was observed. Results suggest that during osteogenic differentiation, EMF exposure increased P2X7 expression by h-MSC, activating Akt/GSK3?/?-catenin axis and stimulating osteogenesis. This is a promising result for osteoporosis therapy using EMF.

Pubmed Study Link

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925409/

PDF Study Link

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925409/pdf/13287_2019_Article_1497.pdf

Study Categories

bone healing, brittle bone

Authors

[‘Yingchi Zhang’, ‘Wenkai Li’, ‘Chaoxu Liu’, ‘Jiyuan Yan’, ‘Xuefeng Yuan’, ‘Wei Wang’, ‘Huaixi Wang’, ‘Hua Wu’, ‘Yong Yang’]

PMID

31864409

PMCID

PMC6925409

Published Date

more study details

Frequency (Hz)

0, 100

Frequency Range

High

Intensity (G)

0, 50

Intensity Range

High, Low

Waveform

sine

PEMF/EMF/RF/LT

EMF

Study Subject Types

human

Keywords Listed

Electromagnetic fields (EMFs), Purinergic receptor P2X7, Human bone marrow mesenchymal stem cells (h-MSCs), Osteogenic differentiation, Akt/GSK3?/?-catenin signaling pathway

Added Descriptive Keywords

bone, bone marrow, bone formation, muscle, tissue, osteogenesis, osteoporosis, human

Disclaimer

All intellectual property and copyright of this research study sourced from PubMed, is the property of the authors and associates and is not the property of HealthMatReview.com. This research study has been included in our custom PEMF research database for the educational purposes of our readers. The on page summary, added descriptive keywords and other study details are copyright of HealthMatReview.com and were added to improve the search function of this custom research database.

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