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Our Summary
The objective of this study is to investigate the effects of EMF on purinergic receptor P2X7 and its potential in osteoporosis therapy. Human bone marrow mesenchymal stem cells (h-MSC) were exposed to EMF and P2X7 expression was observed. Results suggest that during osteogenic differentiation, EMF exposure increased P2X7 expression by h-MSC, activating Akt/GSK3?/?-catenin axis and stimulating osteogenesis. This is a promising result for osteoporosis therapy using EMF.
Pubmed Study Link
PDF Study Link
Study Categories
Authors
[‘Yingchi Zhang’, ‘Wenkai Li’, ‘Chaoxu Liu’, ‘Jiyuan Yan’, ‘Xuefeng Yuan’, ‘Wei Wang’, ‘Huaixi Wang’, ‘Hua Wu’, ‘Yong Yang’]
PMID
31864409
PMCID
PMC6925409
Published Date
more study details
Frequency (Hz)
Frequency Range
Intensity (G)
Intensity Range
Waveform
PEMF/EMF/RF/LT
Study Subject Types
Keywords Listed
Electromagnetic fields (EMFs), Purinergic receptor P2X7, Human bone marrow mesenchymal stem cells (h-MSCs), Osteogenic differentiation, Akt/GSK3?/?-catenin signaling pathway
Added Descriptive Keywords
bone, bone marrow, bone formation, muscle, tissue, osteogenesis, osteoporosis, human
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